Document Detail


Cell-fusion-mediated somatic-cell reprogramming: a mechanism for tissue regeneration.
MedLine Citation:
PMID:  20049847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Spontaneous cell fusion between two cells of different lineages will originate new hybrid cells that have different features from the original parent cells. It has been shown that injury to a tissue can enhance spontaneous cell-cell fusion events. If one of the parent cells of a cell-cell fusion is highly plastic, such as a stem cell, and the other is a somatic cell, their fusion can be followed by reprogramming events that can generate new hybrid pluripotent cells. These, in turn, have the potential to differentiate and regenerate the damaged tissue. However, if this process is deregulated, this would provide a mechanism for cancer development.
Authors:
Frederic Lluis; Maria Pia Cosma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of cellular physiology     Volume:  223     ISSN:  1097-4652     ISO Abbreviation:  J. Cell. Physiol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-03-08     Revised Date:  2011-11-24    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6-13     Citation Subset:  IM    
Copyright Information:
J. Cell. Physiol. 223: 6-13, 2010. (c) 2009 Wiley-Liss, Inc.
Affiliation:
Telethon Institute of Genetics and Medicine and Institute of Genetics and Biophysics, CNR, Naples, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Fusion*
Cell Lineage
Cell Proliferation*
Cell Transdifferentiation* / genetics
Gene Expression Regulation
Humans
Hybrid Cells
Neoplastic Stem Cells / pathology
Regeneration* / genetics
Stem Cells*
Grant Support
ID/Acronym/Agency:
TGM06C02//Telethon

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