Document Detail

Cell fusion in the filamentous fungus, Neurospora crassa.
MedLine Citation:
PMID:  18979236     Owner:  NLM     Status:  MEDLINE    
Hyphal fusion occurs at different stages in the vegetative and sexual life cycle of filamentous fungi. Similar to cell fusion in other organisms, the process of hyphal fusion requires cell recognition, adhesion, and membrane merger. Analysis of the hyphal fusion process in the model organism Neurospora crassa using fluorescence and live cell imaging as well as cell and molecular biological techniques has begun to reveal its complex cellular regulation. Several genes required for hyphal fusion have been identified in recent years. While some of these genes are conserved in other eukaryotic species, other genes encode fungal-specific proteins. Analysis of fusion mutants in N. crassa has revealed that genes previously identified as having nonfusion-related functions in other systems have novel hyphal fusion functions in N. crassa. Understanding the molecular basis of cell fusion in filamentous fungi provides a paradigm for cell communication and fusion in eukaryotic organisms. Furthermore, the physiological and developmental roles of hyphal fusion are not understood in these organisms; identifying these mechanisms will provide insight into environmental adaptation.
André Fleissner; Anna R Simonin; N Louise Glass
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  475     ISSN:  1064-3745     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-03     Completed Date:  2008-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-38     Citation Subset:  IM    
Department of Plant and Microbial Biology, The University of California, Berkeley, CA, USA.
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MeSH Terms
Hyphae / cytology
Membrane Fusion*
Mutation / genetics
Neurospora crassa / cytology*,  genetics

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