Document Detail


Cell fusion in Caenorhabditis elegans.
MedLine Citation:
PMID:  18979238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the nematode Caenorhabditis elegans, 300 of the 959 somatic nuclei present in the adult hermaphrodite are located in syncytia. These syncytia are formed by the fusion of mononucleate cells throughout embryonic and postembryonic development. These cell fusions occur in a well-characterized stereotypical pattern, allowing investigators to study many cell fusion events at the molecular and cellular levels. Using tools that allow visualization of cell membranes, cell junctions, and cell cytoplasm during fusion, genetic screens have identified many C. elegans cell fusion genes, including those that regulate the fusion cell fate decision and two genes that encode components of the cell fusion machinery.
Authors:
Scott Alper; Benjamin Podbilewicz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  475     ISSN:  1064-3745     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-03     Completed Date:  2008-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  53-74     Citation Subset:  IM    
Affiliation:
Laboratory of Respiratory Biology, NIEHS, NIH, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Caenorhabditis elegans / cytology*,  embryology,  genetics
Caenorhabditis elegans Proteins / metabolism
Cell Fusion
Epidermis / cytology
Epithelial Cells / cytology
Larva / cytology
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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