| Cell fusion in Caenorhabditis elegans. | |
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MedLine Citation:
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PMID: 18979238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the nematode Caenorhabditis elegans, 300 of the 959 somatic nuclei present in the adult hermaphrodite are located in syncytia. These syncytia are formed by the fusion of mononucleate cells throughout embryonic and postembryonic development. These cell fusions occur in a well-characterized stereotypical pattern, allowing investigators to study many cell fusion events at the molecular and cellular levels. Using tools that allow visualization of cell membranes, cell junctions, and cell cytoplasm during fusion, genetic screens have identified many C. elegans cell fusion genes, including those that regulate the fusion cell fate decision and two genes that encode components of the cell fusion machinery. |
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Authors:
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Scott Alper; Benjamin Podbilewicz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Methods in molecular biology (Clifton, N.J.) Volume: 475 ISSN: 1064-3745 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-11-03 Completed Date: 2008-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 53-74 Citation Subset: IM |
Affiliation:
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Laboratory of Respiratory Biology, NIEHS, NIH, Department of Medicine, Duke University Medical Center, Durham, NC, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caenorhabditis elegans / cytology*, embryology, genetics Caenorhabditis elegans Proteins / metabolism Cell Fusion Epidermis / cytology Epithelial Cells / cytology Larva / cytology |
| Chemical | |
Reg. No./Substance:
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0/Caenorhabditis elegans Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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