Document Detail


Cell-free biology: exploiting the interface between synthetic biology and synthetic chemistry.
MedLine Citation:
PMID:  22483202     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Just as synthetic organic chemistry once revolutionized the ability of chemists to build molecules (including those that did not exist in nature) following a basic set of design rules, cell-free synthetic biology is beginning to provide an improved toolbox and faster process for not only harnessing but also expanding the chemistry of life. At the interface between chemistry and biology, research in cell-free synthetic systems is proceeding in two different directions: using synthetic biology for synthetic chemistry and using synthetic chemistry to reprogram or mimic biology. In the coming years, the impact of advances inspired by these approaches will make possible the synthesis of nonbiological polymers having new backbone compositions, new chemical properties, new structures, and new functions.
Authors:
D Calvin Harris; Michael C Jewett
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-04-04
Journal Detail:
Title:  Current opinion in biotechnology     Volume:  23     ISSN:  1879-0429     ISO Abbreviation:  Curr. Opin. Biotechnol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-09     Completed Date:  2013-04-12     Revised Date:  2014-04-09    
Medline Journal Info:
Nlm Unique ID:  9100492     Medline TA:  Curr Opin Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  672-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Cell-Free System*
Chemistry Techniques, Synthetic / methods*
Polymers / chemistry
Protein Biosynthesis
Synthetic Biology / methods*
Grant Support
ID/Acronym/Agency:
R00 GM081450/GM/NIGMS NIH HHS; R00GM081450/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Polymers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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