Document Detail

Cell division in blue-green bacteria: stimulation of localized regions of peptidoglycan metabolism by ethanol.
MedLine Citation:
PMID:  810643     Owner:  NLM     Status:  MEDLINE    
D-Cycloserine was used to localize regions of active peptidoglycan metabolism as bulged, weakened areas in the lateral wall. Strain SN29 is a non-septate filamentous mutant of Agmenellum quadruplicatum and produces one to two such bulges per filament during exponential growth in the presence of D-cycloserine. The addition of ethanol to D-cycloserine inhibited filaments results in the production of many additional bulges in the lateral wall and is interpreted as evidence for the localized activation of peptidoglycan metabolism by ethanol. In the parent organism, D-cycloserine selectively inhibits cell division resulting in the formation of enlarged spindle-shaped cells. Cell separation was also affected. Chain formation was greatly reduced in septate mutants of A. quadruplicatum by growth in the presence of D-cycloserine. This was apparently due to the increase fragility of cells within the filaments.
J A Sturgeon; H A Aldrich; L O Ingram
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Microbios     Volume:  12     ISSN:  0026-2633     ISO Abbreviation:  Microbios     Publication Date:  1975  
Date Detail:
Created Date:  1976-01-29     Completed Date:  1976-01-29     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0207257     Medline TA:  Microbios     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  143-54     Citation Subset:  IM    
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MeSH Terms
Cell Division / drug effects
Cell Wall / metabolism,  ultrastructure
Cyanobacteria / cytology*,  metabolism,  ultrastructure
Cycloserine / pharmacology
Ethanol / pharmacology*
Peptidoglycan / biosynthesis*
Reg. No./Substance:
0/Peptidoglycan; 64-17-5/Ethanol; 68-41-7/Cycloserine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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