| Cell division in the CNS: protective response or lethal event in post-mitotic neurons? | |
| | |
MedLine Citation:
|
PMID: 17158035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cell cycle events have been documented to be associated with several human neurodegenerative diseases. This review focuses on two diseases--Alzheimer's disease and ataxia telangiectasia--as well as their mouse models. Cell cycle studies have shown that ectopic expression of cell cycle markers is spatially and regional correlated well with neuronal cell death in both disease conditions. Further evidence of ectopic cell cycling is found in both human diseases and in its mouse models. These findings suggest that loss of cell cycle control represents a common pathological root of disease, which underlies the defects in the affected brain tissues in both human and mouse. Loss of cell cycle control is a unifying hypothesis for inducing neuronal death in CNS. In the disease models we have examined, cell cycle markers appear before the more well-recognized pathological changes and thus could serve as early stress markers--outcome measures for preclinical trials of potential disease therapies. As a marker these events could serve as a new criterion in human pathological diagnosis. The evidence to date is compatible with the requirement for a second "hit" for a neuron to progress cell cycle initiation and DNA replication to death. If this were true, any intervention of blocking 'second' processes might prevent or slow the neuronal cell death in the process of disease. What is not known is whether, in an adult neuron, the cell cycle event is part of the pathology or rather a desperate attempt of a neuron under stress to protect itself. |
| | |
Authors:
|
Yan Yang; Karl Herrup |
Related Documents
:
|
10878255 - Chemical inhibitors: a tool for plant cell cycle studies. 14767065 - Cell cycle-dependent expression of thyroid hormone receptor-beta is a mechanism for var... 12145325 - Lytic replication-associated protein (rap) encoded by kaposi sarcoma-associated herpesv... 14756785 - Mutations of the ck2 phosphorylation site of sic1 affect cell size and s-cdk kinase act... 9182585 - Isolation of mitochondrial dna-less mouse cell lines and their application for trapping... 2414315 - Voltage-dependent ion channels in t-lymphocytes. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2006-10-07 |
Journal Detail:
|
Title: Biochimica et biophysica acta Volume: 1772 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2007 Apr |
Date Detail:
|
Created Date: 2007-03-19 Completed Date: 2007-04-26 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 457-66 Citation Subset: IM |
Affiliation:
|
Department of Neurology, University Hospitals of Cleveland, Alzheimer Research Lab, E504, Case Western Reserve University School of Medicine, 10900 Euclid Avenue Cleveland, OH 44106, USA. yxy33@case.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alzheimer Disease
/
pathology Animals Ataxia Telangiectasia / pathology Cell Division* Disease Models, Animal Disease Progression Humans Mice Mitosis Nerve Degeneration / pathology Neurons / cytology*, pathology |
| Grant Support | |
ID/Acronym/Agency:
|
AG08012/AG/NIA NIH HHS; NS20591/NS/NINDS NIH HHS; P50 AG008012-16S2/AG/NIA NIH HHS; R01 NS020591-23/NS/NINDS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hospital-treated physical illnesses and mortality: an 11-year follow-up study of long-stay psychiatr...
Next Document: Comparison of high-resolution solid-state NMR MQMAS and STMAS methods for half-integer quadrupolar n...