Document Detail


Cell-derived microparticules: Key players at the crossroad between inflammation and thrombosis.
MedLine Citation:
PMID:  21444231     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cell-derived microparticles are complex vesicular structures that can be shedded by activated or apoptotic endothelial cells. Cell-derived microparticles are composed of a phospholipid bilayer that exposes transmembrane proteins and receptors and encloses cytosolic components such as enzymes, transcription factors and mRNA derived from their parent cells. Thus, they behave as biological conveyors playing a key role in the tuning of vascular homeostasis. This review will address the potential of microparticles as efficient vectors of biological activities in pathologies. Based on the model of endothelial vesiculation, the first part of this review will develop the contribution of endothelial microparticles to coagulation inflammation and angiogenesis and their role in vascular disorders. The second part will be focused on the multifaceted impact of cell-derived microparticles present in blood products and its relevance to transfusion medicine.
Authors:
F Sabatier; R Lacroix; A-S Leroyer; S Cointe; F Dignat-George
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-26
Journal Detail:
Title:  Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine     Volume:  -     ISSN:  1953-8022     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423846     Medline TA:  Transfus Clin Biol     Country:  -    
Other Details:
Languages:  FRE     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
Affiliation:
Inserm UMR-S 608, UFR de pharmacie, 27, boulevard Jean-Moulin, 13385 Marseille cedex 5, France; Université de la méditerranée Aix-Marseille II, 27, boulevard Jean-Moulin, 13385 Marseille cedex 5, France; Laboratoire de culture et thérapie cellulaire, centre hospitalier universitaire La-Conception, Assistance publique-Hôpitaux de Marseille, 147, boulevard Baille, 13005 Marseille, France; Inserm CIC BT-510, centre hospitalier universitaire La-Conception, 147, boulevard Baille, 13005 Marseille, France.
Vernacular Title:
Rôle des microparticules cellulaires à l'interface des réponses prothrombotiques et inflammatoires.
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