Document Detail

Cell-derived microparticles and vascular pregnancy complications: a systematic and comprehensive review.
MedLine Citation:
PMID:  23122952     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To assess current studies on the relationship between cell-derived microparticles (cMP) and recurrent miscarriages (RM) and pre-eclampsia (PE), and review the relationships between cMP and inflammatory and clot pathways, antiphospholipid antibodies (aPL), cytokines, and pregnancy complications. DESIGN: Systematic and comprehensive review of the literature from January 2000 to January 2012. SETTING: Vall d'Hebron University Hospital. PATIENT(S): Women with recurrent miscarriages or PE, healthy nonpregnant women, and healthy pregnant women. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Comparison of cMP numbers and types among groups. RESULT(S): Platelet and endothelial cMP are increased in women with normal pregnancies compared with nonpregnant healthy women. Only five case-control studies regarding cMP and RM and 16 on cMP and PE were found to match our objective. Three of five articles referring to RM showed differences in cMP numbering, and 13 of 16 on cMP and PE showed differences in some type of cMP compared with controls. CONCLUSION(S): Cell-derived microparticles were raised in normal pregnancy. Recurrent miscarriage seems to be related to endothelial and platelet cell activation and/or consumption. An increase in almost all cMP types was observed in PE. A relationship between cMP and endothelial activation and proinflammatory status seems to exist.
Jaume Alijotas-Reig; Carles Palacio-Garcia; Elisa Llurba; Miquel Vilardell-Tarres
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-1
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Aging and Systemic Autoimmune Disease Unit, Department of Internal Medicine I, Vall d'Hebron University Hospital, Barcelona, Spain; Department of Medicine, Faculty of Medicine, Universitat Autonoma, Barcelona, Spain. Electronic address:
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