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Cell density-dependent acetylation of ΔNp63α is associated with p53-dependent cell cycle arrest.
MedLine Citation:
PMID:  22575646     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ΔNp63α is a p63 isoform that is predominantly expressed in the epidermal stem cells and in cancer. To find the regulatory pathways of ΔNp63α, we assessed whether ΔNp63α is acetylated and determined the functional implications of acetylation. First, the hinge region of p63 was shown to be acetylated by PCAF, similarly to other p53 family members. Second, acetylation synergistically induced cytoplasmic localization of ΔNp63α. Finally, acetyl-ΔNp63α was induced during high-density culture, suggesting that acetylation of ΔNp63α may reinforce cell cycle arrest upon cell contact. Altogether, these findings suggest that acetylation of ΔNp63α contributes to the epidermal homeostasis. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: PCAFacetylatesΔNp63α by acetylation assay (View Interaction: 1, 2, 3) ΔNp63αphysically interacts with ΔNp63α by anti tag coimmunoprecipitation (View interaction) ΔNp63αphysically interacts with p53 by anti bait coimmunoprecipitation (View interaction).
Authors:
Yang-Seok Chae; Hyunji Kim; Dongsung Kim; Hyunsook Lee; Hae-Ock Lee
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-23
Journal Detail:
Title:  FEBS letters     Volume:  586     ISSN:  1873-3468     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-5-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1128-1134     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Affiliation:
Department of Pathology, Korea University School of Medicine, Seoul, Republic of Korea.
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