Document Detail

Cell delivery therapeutics for musculoskeletal regeneration.
MedLine Citation:
PMID:  20398712     Owner:  NLM     Status:  MEDLINE    
The last decade has witnessed the development of cell-based therapy as a major biomedical research area, including the treatment of musculoskeletal diseases. Both differentiated and undifferentiated stem cells have been used as starting cell sources. In particular, the use of multipotent adult mesenchymal stem cells holds great promise for future therapeutic strategies. In addition to the cell type used, the cell delivery system is also of critical importance in cell-based therapy. Cell delivery may be achieved by direct cell injection or by grafting engineered constructs derived by cell seeding into natural or synthetic biomaterial scaffolds. While direct injection is the most direct and convenient means of cell delivery, the latter approach is capable of producing three-dimensional engineered tissues with mechanical properties compatible with those of various musculoskeletal tissues. This review will focus on the functional approach of using biomaterial scaffold materials as cell carriers for musculoskeletal applications, as well as the use of cell-based gene therapy for tissue engineering and regeneration.
Ulrich Nöth; Lars Rackwitz; Andre F Steinert; Rocky S Tuan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-04-14
Journal Detail:
Title:  Advanced drug delivery reviews     Volume:  62     ISSN:  1872-8294     ISO Abbreviation:  Adv. Drug Deliv. Rev.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710523     Medline TA:  Adv Drug Deliv Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  765-83     Citation Subset:  IM    
Copyright Information:
2010 Elsevier B.V. All rights reserved.
Orthopaedic Center for Musculoskeletal Research, Department of Orthopaedic Surgery, König-Ludwig-Haus, Julius-Maximilians-University, Würzburg, Germany.
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MeSH Terms
Biocompatible Materials / therapeutic use
Cell Differentiation
Cell Transplantation / methods*
Gene Therapy / methods
Musculoskeletal Diseases / pathology,  therapy*
Stem Cell Transplantation / methods
Tissue Engineering / methods*
Tissue Scaffolds
Reg. No./Substance:
0/Biocompatible Materials

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