Document Detail

Cell-delivery therapeutics for adipose tissue regeneration.
MedLine Citation:
PMID:  20394786     Owner:  NLM     Status:  MEDLINE    
In reconstructive surgery, there is a tremendous clinical need for adequate implants to repair soft tissue defects resulting from traumatic injury, tumor resection, or congenital anomalies. Adipose tissue engineering holds the promise to provide answers to this still increasing demand. The current approaches to adipose tissue engineering are comprehensively reviewed detailing the different cell carriers under investigation. A special focus is put on the applied cells. The delivered mesenchymal stem cells act in a dual role as building block of the new tissue and modulators of the host response. The conditioning of the cells in vitro prior to implantation decisively influences the tissue development and long-term survival in vivo. The special role of vascularization in adipose engineering is discussed. In all parts, key messages are defined providing the base for future advances in the generation of fat substitutes.
Petra Bauer-Kreisel; Achim Goepferich; Torsten Blunk
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-04-13
Journal Detail:
Title:  Advanced drug delivery reviews     Volume:  62     ISSN:  1872-8294     ISO Abbreviation:  Adv. Drug Deliv. Rev.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710523     Medline TA:  Adv Drug Deliv Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  798-813     Citation Subset:  IM    
Copyright Information:
2010 Elsevier B.V. All rights reserved.
Department of Trauma, Hand, Plastic & Reconstructive Surgery, University of Würzburg, Germany.
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MeSH Terms
Adipose Tissue / cytology,  metabolism*
Cell Transplantation / methods*
Mesenchymal Stem Cell Transplantation / methods
Reconstructive Surgical Procedures / methods
Tissue Engineering / methods*
Transplantation Conditioning / methods

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