| Cell death signalling pathways in the pathogenesis and therapy of haematologic malignancies: overview of therapeutic approaches. | |
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MedLine Citation:
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PMID: 17116284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Malignant diseases, including haematologic malignancies, are associated with defects in the cell death mechanism. These defects are not only important for the growth advantage of the malignant clone, but when understood can be used for specific therapeutic targeting of malignant cells while sparing normal cells. The promising groups of agents that trigger, directly or indirectly, apoptosis of haematologic cancer cells are reviewed in this article. Some of the agents have recently been approved for therapy, some are under the clinical evaluation in various phases of clinical trials and some are tested under the experimental laboratory conditions. |
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Authors:
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P Klener; L Andera; P Klener; E Necas; J Zivný |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Folia biologica Volume: 52 ISSN: 0015-5500 ISO Abbreviation: Folia Biol. (Praha) Publication Date: 2006 |
Date Detail:
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Created Date: 2006-11-22 Completed Date: 2007-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0234640 Medline TA: Folia Biol (Praha) Country: Czech Republic |
Other Details:
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Languages: eng Pagination: 119-36 Citation Subset: IM |
Affiliation:
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Department of Pathophysiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* Apoptosis Regulatory Proteins / metabolism Cell Cycle Hematologic Neoplasms / genetics, pathology*, therapy* Humans Signal Transduction* Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Apoptosis Regulatory Proteins |
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