Document Detail

Cell death signalling pathways in the pathogenesis and therapy of haematologic malignancies: overview of therapeutic approaches.
MedLine Citation:
PMID:  17116284     Owner:  NLM     Status:  MEDLINE    
Malignant diseases, including haematologic malignancies, are associated with defects in the cell death mechanism. These defects are not only important for the growth advantage of the malignant clone, but when understood can be used for specific therapeutic targeting of malignant cells while sparing normal cells. The promising groups of agents that trigger, directly or indirectly, apoptosis of haematologic cancer cells are reviewed in this article. Some of the agents have recently been approved for therapy, some are under the clinical evaluation in various phases of clinical trials and some are tested under the experimental laboratory conditions.
P Klener; L Andera; P Klener; E Necas; J Zivný
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Folia biologica     Volume:  52     ISSN:  0015-5500     ISO Abbreviation:  Folia Biol. (Praha)     Publication Date:  2006  
Date Detail:
Created Date:  2006-11-22     Completed Date:  2007-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0234640     Medline TA:  Folia Biol (Praha)     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  119-36     Citation Subset:  IM    
Department of Pathophysiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
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MeSH Terms
Apoptosis Regulatory Proteins / metabolism
Cell Cycle
Hematologic Neoplasms / genetics,  pathology*,  therapy*
Signal Transduction*
Transcription, Genetic
Reg. No./Substance:
0/Apoptosis Regulatory Proteins

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