Document Detail


Cell death regulation by B-cell lymphoma protein.
MedLine Citation:
PMID:  16547596     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bcl-2 (B Cell Lymphoma) protein is an anti-apoptotic member of Bcl-2 family, which is comprised of pro- and anti-apoptotic members. It regulates cellular proliferation and death by inter- and intra-family interactions. It has a potential to suppress apoptotic cell death under variety of stress conditions by modulating mitochondrial transmembrane potential. However, prevalence of constitutively activated Bcl-2 cellular activity is not always required in cells; a mechanism likely exists in cells, which controls its activity. When expression of Bcl-2 is unregulated, it generates lymphoma like, follicular B-cell lymphoma. This article reviews the structural and functional regulation of Bcl-2 activity at transcriptional, translational, domain, structural and post-translational level, which also accounts for the effects of its deletion and site-directed mutants in the regulation of cellular proliferation and differentiation in vitro and in vivo. This concisely reviewed information on Bcl-2 helps us to update our understanding of cell death and its modulation by Bcl-2 and its mutant's interaction, which has gained therapeutic benefits in cell growth and proliferation, particularly for sensitive human hematopoietic stem cells.
Authors:
Y K Verma; G U Gangenahalli; V K Singh; P Gupta; R Chandra; R K Sharma; H G Raj
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Apoptosis : an international journal on programmed cell death     Volume:  11     ISSN:  1360-8185     ISO Abbreviation:  Apoptosis     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-05-04     Completed Date:  2006-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9712129     Medline TA:  Apoptosis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  459-71     Citation Subset:  IM    
Affiliation:
Stem Cell Gene Therapy Research Group, Lucknow Road, Timar Pur, Delhi, 110054, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis*
Caspase 9
Caspases / metabolism
Gene Expression Regulation
Mutation
Protein Structure, Tertiary
Proto-Oncogene Proteins c-bcl-2 / chemistry,  genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-bcl-2; EC 3.4.22.-/CASP9 protein, human; EC 3.4.22.-/Caspase 9; EC 3.4.22.-/Caspases

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