| Cell death: questions for histochemists concerning the causes of the various cytological changes. | |
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MedLine Citation:
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PMID: 6171549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The question of cell death is accessible to study by histochemists and many questions remain to be resolved. From a physiological point of view, the most important are the causal relationships. (1) At what phase in cell death is the synthesis of RNA disrupted and at what phase is the rate of degradation of RNA increased? (2) Does the disruption of synthesis result from a direct genetic command, or does it result indirectly from gradual deterioration of energy resources or optimal ionic conditions? (3) What properties, presumably of the substrate organelles, marks them for specific absorption into autophagic vacuoles? (4) What proteases and other hydrolases operate currently undetected in the cytoplasm? How are they controlled and regulated? (5) Why does the physiologically dying cell shrink and appear more dense? To what extent is a cell in this state able to regulate any metabolic parameter? The advent of newer, more sensitive and quantitative techniques, and greater attention to the controls and causes as opposed to the phenomena, should help to resolve these questions. |
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Authors:
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R A Lockshin; J Beaulaton |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Histochemical journal Volume: 13 ISSN: 0018-2214 ISO Abbreviation: Histochem. J. Publication Date: 1981 Jul |
Date Detail:
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Created Date: 1982-02-22 Completed Date: 1982-02-22 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0163161 Medline TA: Histochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 659-66 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Survival* Histocytochemistry Lysosomes / metabolism Microscopy, Electron Muscles / pathology RNA / metabolism |
| Chemical | |
Reg. No./Substance:
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63231-63-0/RNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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