| Cell death pathways and autophagy in the central nervous system and its involvement in neurodegeneration, immunity and central nervous system infection: to die or not to die--that is the question. | |
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MedLine Citation:
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PMID: 22385237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Death rules our lives. In this short paper, we summarize new insights into molecular mechanisms of neurodegeneration. Here we review the most important processes of cell death: apoptosis and oncosis. We focus on autophagy, which is pivotal for neuronal homeostasis, in the context of neurodegeneration, infection and immunity. Its dysfunction has been linked to several neurodegenerative diseases such as Parkinson's, Huntington's and Alzheimer's diseases. Our understanding is still incomplete, but may highlight attractive new avenues for the development of treatment strategies to combat neurodegenerative diseases. |
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Authors:
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A Rosello; G Warnes; U-C Meier |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 168 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-05 Completed Date: 2012-05-04 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 52-7 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology. |
Affiliation:
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Neuroimmunology Group, Centre for Neuroscience and Trauma, Flow Cytometry Group, Blizard Institute, Queen Mary University of London, Barts and The London, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* Autophagy* Central Nervous System / physiology* Central Nervous System Viral Diseases / immunology, physiopathology* Humans Mice Neurodegenerative Diseases / immunology, physiopathology*, virology Neurons / physiology* |
| Comments/Corrections | |
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