| Cell-death-mode switch from necrosis to apoptosis in hydrogen peroxide treated macrophages. | |
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MedLine Citation:
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PMID: 20953942 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Cell death is typically defined either as apoptosis or necrosis. Because the consequences of apoptosis and necrosis are quite different for an entire organism, the investigation of the cell-death-mode switch has considerable clinical significance. The existence of a necrosis-to-apoptosis switch induced by hydrogen peroxide in macrophage cell line RAW 264.7 cells was confirmed by using flow cytometry and fluorescence microscopy. With the help of computational simulations, this study predicted that negative feedbacks between NF-κB and MAPKs are implicated in converting necrosis into apoptosis in macrophages exposed to hydrogen peroxide, which has significant implications. |
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Authors:
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XuZhu Lin; TingZhe Sun; MeiHong Cai; PingPing Shen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-17 |
Journal Detail:
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Title: Science China. Life sciences Volume: 53 ISSN: 1869-1889 ISO Abbreviation: Sci China Life Sci Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101529880 Medline TA: Sci China Life Sci Country: China |
Other Details:
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Languages: eng Pagination: 1196-203 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Nanjing University, Nanjing, 210093, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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