Document Detail


Cell death mechanisms at the maternal-fetal interface: insights into the role of granulysin.
MedLine Citation:
PMID:  21912564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During mammal pregnancy, a sensitive balance between hormones, cytokines, humoral factors, and local cellular interactions must be established. Cytotoxic cells infiltrating the decidua are heavily equipped with cytolytic molecules, in particular perforin and granulysin. Granulysin is especially abundant in NK cells which are able to spontaneously secrete high quantities of granulysin. Besides being a potent bactericidal and tumoricidal molecule, granulysin is also found to be a chemoattractant and a proinflammatory molecule. The precise role(s) of granulysin at the maternal-fetal interface has not been elucidated yet. It is possible that it behaves as a double-edged sword simultaneously acting as an immunomodulatory and a host defense molecule protecting both the mother and the fetus from a wide spectrum of pathogens, and on the other hand, in case of an NK cell activation, acting as an effector molecule causing the apoptosis of semiallograft trophoblast cells and consequently leading to various pregnancy disorders or pregnancy loss.
Authors:
Danijela Veljkovic Vujaklija; Sonja Sucic; Tamara Gulic; Marin Dominovic; Daniel Rukavina
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-09-08
Journal Detail:
Title:  Clinical & developmental immunology     Volume:  2012     ISSN:  1740-2530     ISO Abbreviation:  Clin. Dev. Immunol.     Publication Date:  2012  
Date Detail:
Created Date:  2011-09-13     Completed Date:  2012-01-10     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101183692     Medline TA:  Clin Dev Immunol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  180272     Citation Subset:  IM    
Affiliation:
Department of Physiology and Immunology, University of Rijeka, Rijeka, Croatia.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / immunology*
Animals
Antigens, Differentiation, T-Lymphocyte / immunology,  metabolism*
Apoptosis
Cytotoxicity, Immunologic
Female
Graft Rejection / immunology*
Humans
Killer Cells, Natural / immunology*
Lymphocyte Activation
Mammals
Maternal-Fetal Exchange / immunology
Pregnancy
Trophoblasts / immunology,  metabolism*,  pathology
Chemical
Reg. No./Substance:
0/Antigens, Differentiation, T-Lymphocyte; 0/GNLY protein, human
Comments/Corrections

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