Document Detail

Cell death in mammalian development.
MedLine Citation:
PMID:  18220829     Owner:  NLM     Status:  MEDLINE    
During embryogenesis there is an exquisite orchestration of cellular division, movement, differentiation, and death. Cell death is one of the most important aspects of organization of the developing embryo, as alteration in timing, level, or pattern of cell death can lead to developmental anomalies. Cell death shapes the embryo and defines the eventual functions of the organs. Cells die using different paths; understanding which path a dying cell takes helps us define the signals that regulate the fate of the cell. Our understanding of cell death in development stems from a number of observations indicating genetic regulation of the death process. With today's increased knowledge of the pathways of cell death and the identification of the genes whose products regulate the pathways we know that, although elimination of some of these gene products has no developmental phenotype, alteration of several others has profound effects. In this review we discuss the types and distributions of cell death seen in developing mammalian embryos as well as the gene products that may regulate the process.
C Penaloza; S Orlanski; Y Ye; T Entezari-Zaher; M Javdan; Z Zakeri
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  14     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2008  
Date Detail:
Created Date:  2008-01-28     Completed Date:  2008-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  184-96     Citation Subset:  IM    
Department of Biology, Queens College and Graduate Center of the City University of New York, Flushing, New York 11367, USA.
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MeSH Terms
Apoptosis / drug effects,  genetics,  physiology*
Autophagy / drug effects,  genetics,  physiology*
Cell Death
Congenital Abnormalities / etiology,  pathology
Embryonic Development / genetics,  physiology*
Mammals / embryology*
Teratogens / toxicity
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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