Document Detail

Cell death during early morphogenesis: parallels between insect limb and vertebrate limb development.
MedLine Citation:
PMID:  5773109     Owner:  NLM     Status:  MEDLINE    
The complex jointed leg of the adult fly is derived, in the pupal stage, from a simple lobed sac of cells. The gross morphological changes that result in adult shape are effected by a combination of differential cell growth and the programmed death of a large number of imaginal disc cells. Events are closely similar to those occurring in digit formation and limb contouring during vertebrate morphogenesis. In both cases phagocytic blood cells are intimately involved.
J M Whitten
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  163     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1969 Mar 
Date Detail:
Created Date:  1969-04-22     Completed Date:  1969-04-22     Revised Date:  2011-12-07    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1456-7     Citation Subset:  IM    
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MeSH Terms
Biological Clocks
Diptera / growth & development*
Extremities / growth & development*
Physiology, Comparative

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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