Document Detail

Cell death atlas of the postnatal mouse ventral forebrain and hypothalamus: Effects of age and sex.
MedLine Citation:
PMID:  23296992     Owner:  NLM     Status:  Publisher    
Naturally-occurring cell death is essential to the development of the mammalian nervous system. Although the importance of developmental cell death has been appreciated for decades, there is no comprehensive account of cell death across brain areas in the mouse. Moreover, several regional sex differences in cell death have been described inthe ventral forebrain and hypothalamus, but it is not known how widespread the phenomenon is. We used immunohistochemical detection of activated caspase-3 to identify dying cells in the brains of male and female mice from postnatal day (P)1 to P11. Cell death density, total number of dying cells, and regional volume were determined in 16 regions of the hypothalamus and ventral forebrain(the anterior hypothalamus, arcuate nucleus, anteroventral periventricular nucleus, medial preoptic nucleus, paraventricular nucleus, suprachiasmatic nucleus and ventromedial nucleus of the hypothalamus;the basolateral, central and medial amygdala; the lateral and principal nuclei of the bed nuclei of the striaterminalis; the caudate-putamen, globuspallidus, lateral septum, and Islands of Calleja). All regions showed a significant effect of age on cell death. The timing of peak cell death varied between P1 to P7 and the average rate of cell death varied10-fold among regions. Several significant sex differences in cell death and/or regional volume were detected. These data address large gaps in the developmental literature and suggest interesting region-specific differences in the prevalence and timing of cell death in the hypothalamus and ventral forebrain. J. Comp. Neurol., 2013. © 2013 Wiley Periodicals, Inc.
Todd H Ahern; Stefanie Krug; Audrey V Carr; Elaine K Murray; Emmett Fitzpatrick; Lynn Bengston; Jill McCutcheon; Geert J De Vries; Nancy G Forger
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-8
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  -     ISSN:  1096-9861     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
Center for Behavioral Neuroscience, Department of Psychology, Quinnipiac University, Hamden CT, USA 06518, USA; Department of Psychology, Center for Neuroendocrine Studies, University of Massachusetts, Amherst MA, USA 01003, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Engineering Escherichia coli for renewable production of the 5-carbon polyamide building-blocks 5-am...
Next Document:  Endogenous extracellular matrices enhance human mesenchymal stem cell aggregate formation and surviv...