Document Detail


Cell death: apoptosis versus necrosis (review).
MedLine Citation:
PMID:  12063564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell death and the subsequent post-mortem changes, called necrosis, are integral parts of normal development and maturation cycle. Despite the importance of this process, the mechanisms underlying cell death are still poorly understood. In the recent literature, cell death is said to occur by two alternative, opposite modes: apoptosis, a programmed, managed form of cell death, and necrosis, an unordered and accidental form of cellular dying. The incorrect consequence is the overlapping of: a) the process whereby cells die, cell death; and b) the changes that the cells and tissues undergo after the cells die. Only the latter process can be referred to as necrosis and represents a <no return> process in cell life. In this review, we discuss the excellent basic research developed in this field during last decades and problems that remain to be resolved in defining both experimentally and mechanicistically the events that lead to and characterize cell death.
Authors:
Darja Kanduc; Abraham Mittelman; Rosario Serpico; Eberta Sinigaglia; Animesh A Sinha; Costanzo Natale; Raffaella Santacroce; M Grazia Di Corcia; Alberta Lucchese; Luciana Dini; Paolo Pani; Salvatore Santacroce; Simone Simone; Romano Bucci; Emanuel Farber
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  International journal of oncology     Volume:  21     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-06-13     Completed Date:  2002-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  165-70     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, USA. d.kanduc@biologia.uniba.it
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis*
Humans
Necrosis*
Neoplasms / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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