Document Detail

Cell damage in vitro following direct contact with fine particles of titanium, titanium alloy and cobalt-chrome-molybdenum alloy.
MedLine Citation:
PMID:  7948594     Owner:  NLM     Status:  MEDLINE    
Fibroblastic cells in vitro were exposed to powders of titanium, titanium-aluminium-vanadium alloy and cobalt-chrome-molybdenum (Co-Cr-Mo) alloy, either in direct contact with the cells or separated from the cells by a microporous membrane. Fine particles of all the materials reduced cell growth when in direct contact with cells, but only the finest particles of Co-Cr-Mo alloy caused cell damage through the microporous membrane. This provides further evidence that there is a mechanism of cell damage in vitro which depends on a direct interaction between cells and particles and is largely independent of the chemical nature of the particle.
E J Evans
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomaterials     Volume:  15     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-12-28     Completed Date:  1994-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  713-7     Citation Subset:  IM    
Department of Anatomy, University of Wales College of Cardiff, UK.
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MeSH Terms
Cell Count / drug effects
Cells, Cultured
Fibroblasts / cytology,  drug effects*
Particle Size
Titanium / toxicity*
Vitallium / toxicity*
Reg. No./Substance:
12629-02-6/Vitallium; 12743-70-3/titanium alloy (TiAl6V4); 7440-32-6/Titanium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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