Document Detail

Cell cycle-specific variation of intracellular plasminogen activator activity in cultured human alveolar epithelial carcinoma and rat hepatoma cells.
MedLine Citation:
PMID:  2752214     Owner:  NLM     Status:  MEDLINE    
Plasminogen activator activity was demonstrated in two carcinoma cell lines: A549 cells derived from a human alveolar epithelial carcinoma; and ZHC cells derived from a rat hepatoma. Both cells had intracellular plasminogen activator activity throughout their cell cycles and in each case this activity reached a maximum. For A549 cells the maximal activity took place either during the G2 phase or in the course of the S to G2 transition, suggesting that plasminogen activator might play a role in cell division. For ZHC cells, the maximal activity occurred at the start of the S phase, suggesting that in these cells plasminogen activator might be involved in DNA replication.
G Orfanoudakis; D Zaoui; J J Befort; J G Bieth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the cell / under the auspices of the European Cell Biology Organization     Volume:  65     ISSN:  0248-4900     ISO Abbreviation:  Biol. Cell     Publication Date:  1989  
Date Detail:
Created Date:  1989-08-31     Completed Date:  1989-08-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8108529     Medline TA:  Biol Cell     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  297-300     Citation Subset:  IM    
Laboratoire de Biologie Cellulaire, Faculté de Pharmacie, Université Louis Pasteur, Illkirch, France.
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MeSH Terms
Liver Neoplasms, Experimental*
Lung Neoplasms*
Plasminogen Activators / metabolism*
Thymidine / diagnostic use
Tumor Cells, Cultured / cytology*,  metabolism
Reg. No./Substance:
50-89-5/Thymidine; EC 3.4.21.-/Plasminogen Activators

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