| Cell-cycle-specific initiation of replication. | |
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MedLine Citation:
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PMID: 7968524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The following characteristics are relevant when replication of chromosomes and plasmids is discussed in relation to the cell cycle: the timing or replication, the selection of molecules for replication, and the coordination of multiple initiation events within a single cell cycle. Several fundamentally different methods have been used to study these processes: Meselson-Stahl density-shift experiments, experiments with the so-called 'baby machine', sorting of cells according to size, and flow cytometry. The evidence for precise timing and co-ordination of chromosome replication in Escherichia coli is overwhelming. Similarly, the high-copy-number plasmid ColE1 and the low-copy-number plasmids R1/R100 without any doubt replicate randomly throughout the cell cycle. Data about the low-copy-number plasmids F and P1 are conflicting. This calls for new types of experiments and for a better understanding of how these plasmids control their replication and partitioning. |
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Authors:
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K Nordström; S J Austin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Molecular microbiology Volume: 10 ISSN: 0950-382X ISO Abbreviation: Mol. Microbiol. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1994-12-08 Completed Date: 1994-12-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8712028 Medline TA: Mol Microbiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 457-63 Citation Subset: IM |
Affiliation:
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Department of Microbiology, Uppsala University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacteriological Techniques*
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instrumentation Cell Cycle* Chromosomes, Bacterial DNA Replication* DNA, Bacterial / chemistry, genetics Escherichia coli / genetics, physiology Flow Cytometry Models, Genetic Plasmids / genetics Replicon |
| Grant Support | |
ID/Acronym/Agency:
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N01-CO-74101/CO/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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