| Cell cycle specific expression and nucleolar localization of human J-domain containing co-chaperone Mrj. | |
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MedLine Citation:
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PMID: 19002655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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J-domain containing co-chaperone Mrj (mammalian relative to DnaJ) has been implicated in diverse cellular functions including placental development and inhibition of Huntingtin mediated cytotoxicity. It has also been shown to interact with keratin intermediate filaments. Since keratins undergo extensive reorganization during cell division, its interactor Mrj might also play an important role in the regulation of cell cycle. In support of this hypothesis, we report the up-regulation of Mrj protein in M-phase of HeLa cells implicating its role in mitosis related activities. The protein is dispersed throughout the cell during late mitosis and is localized in nucleolus during interphase, confirming that the activity of Mrj is regulated by its cell cycle specific expression together with its differential subcellular localization. |
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Authors:
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Sanjib Dey; Paromita Banerjee; Partha Saha |
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Publication Detail:
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Type: Journal Article Date: 2008-11-12 |
Journal Detail:
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Title: Molecular and cellular biochemistry Volume: 322 ISSN: 1573-4919 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-27 Completed Date: 2009-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 137-42 Citation Subset: IM |
Affiliation:
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Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Sector I, Block AF, Bidhannagar, Kolkata, 700064, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle* Cell Nucleolus / metabolism* Fluorescent Antibody Technique HSP40 Heat-Shock Proteins / analysis*, genetics*, metabolism Hela Cells Humans Molecular Chaperones / analysis*, genetics*, metabolism Nerve Tissue Proteins / analysis*, genetics*, metabolism Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/DNAJB6 protein, human; 0/HSP40 Heat-Shock Proteins; 0/Molecular Chaperones; 0/Nerve Tissue Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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