Document Detail


Cell-cycle responses to DNA damage in G2.
MedLine Citation:
PMID:  12503848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cellular reproduction, at its basic level, is simply the passing of genetic information from a single parent cell into two daughter cells. As the cellular genome encodes all the information that defines a cell, it is crucial that the genome be accurately replicated. Furthermore, the duplicated genome must be properly segregated so that each daughter cell contains the exact same information as the parent cell. The processes by which this occurs is known as the cell cycle. The failure of either duplication or segregation of the genome can have disastrous consequences for an organism, including cancer and death. This article discusses what is known about checkpoints, the surveillance mechanisms that monitor both the fidelity and accuracy of DNA replication and segregation. Specifically, we will focus on the G2 checkpoint that is responsible for ensuring proper segregation of the duplicated genome into the daughter cells and how this checkpoint functions to arrest entry into mitosis in response to DNA damage.
Authors:
Andrew R Cuddihy; Matthew J O'Connell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  International review of cytology     Volume:  222     ISSN:  0074-7696     ISO Abbreviation:  Int. Rev. Cytol.     Publication Date:  2003  
Date Detail:
Created Date:  2002-12-30     Completed Date:  2003-06-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2985180R     Medline TA:  Int Rev Cytol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-140     Citation Subset:  IM    
Affiliation:
Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, Melbourne, Victoria 8006 Australia.
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MeSH Terms
Descriptor/Qualifier:
Cell Cycle
Cell Cycle Proteins / metabolism
DNA Damage*
DNA Repair Enzymes
DNA-Binding Proteins*
Endonucleases / genetics,  metabolism
Eukaryotic Cells / cytology
G2 Phase* / genetics,  physiology
Genes, cdc
Receptors, Peptide / genetics,  metabolism
Saccharomyces cerevisiae Proteins
Schizosaccharomyces pombe Proteins*
Signal Transduction
Chemical
Reg. No./Substance:
0/Cell Cycle Proteins; 0/DNA-Binding Proteins; 0/Receptors, Peptide; 0/Saccharomyces cerevisiae Proteins; 0/Schizosaccharomyces pombe Proteins; 0/anthrax toxin receptors; 0/mcm2 protein, S pombe; EC 3.1.-/Endonucleases; EC 3.1.-/RAD1 protein, S cerevisiae; EC 3.1.-/rad1 protein, S pombe; EC 6.5.1.-/DNA Repair Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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