| Cell cycle regulatory molecules (cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors) and the cardiovascular system; potential targets for therapy? | |
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MedLine Citation:
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PMID: 10213344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the preceding sections we have described the potential for using cell cycle regulatory molecules as targets for drug development within the cardiovascular system. Opportunities for affecting the expression and activities of selected cell cycle regulatory molecules exist in interventional cardiological procedures such as PTCA to limit specifically the intimal hyperplasia of vascular smooth muscle cells that occurs following angioplasty. In addition, the potential for targeting the cardiac myocyte cell cycle to re-initiate cell division in a controlled manner would provide a suitable approach for repairing damaged areas of myocardial tissue following an infarct. Although this approach has not been demonstrated to date in vivo, data from transgenic mouse models and in vitro studies have implicated the cell cycle as a suitable target for manipulation. The next few years will enable the feasibility of this approach to be demonstrated. |
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Authors:
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J M Li; G Brooks |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: European heart journal Volume: 20 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-06-08 Completed Date: 1999-06-08 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 406-20 Citation Subset: IM |
Affiliation:
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Cardiovascular Cellular and Molecular Biology, Cardiovascular Research, The Rayne Institute, St. Thomas' Hospital, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiovascular Diseases / drug therapy, metabolism Cardiovascular System / drug effects, metabolism* Cell Cycle / drug effects, physiology Cyclin-Dependent Kinases / antagonists & inhibitors, genetics, metabolism* Cyclins / genetics, metabolism* Endothelium, Vascular / cytology, drug effects, metabolism Humans Mice Muscle, Smooth, Vascular / cytology, drug effects, metabolism Myocardium / cytology, metabolism Oligodeoxyribonucleotides, Antisense / pharmacology* RNA, Messenger / biosynthesis |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Cyclins; 0/Oligodeoxyribonucleotides, Antisense; 0/RNA, Messenger; EC 2.7.11.22/Cyclin-Dependent Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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