| Cell-cycle-regulatory elements and the control of cell differentiation in the budding yeast. | |
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MedLine Citation:
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PMID: 12938175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The stable differentiation of cells into other cell types typically involves dramatic reorganization of cellular structures and functions. This often includes remodeling of the cell cycle and the apparatus that controls it. Here we review our understanding of the role and regulation of cell cycle control elements during cell differentiation in the yeast, Saccharomyces cerevisiae. Although the process of differentiation may be more overtly obvious in metazoan organisms, those systems are by nature more difficult to study at a mechanistic level. We consider the relatively well-understood mechanisms by which mating-type switching and the pheromone-induced differentiation of gametes are coupled to the cell cycle as well as the more obscure mechanisms that govern the remodeling of the cell cycle during meiosis and filamentous growth. In some cases, the cell cycle is a primary stimulus for differentiation whereas, in other cases, the signals that promote differentiation alter the cell cycle. Thus, despite relative simplicity of these processes in yeast, the nature of the interplay between the cell cycle and differentiation is diverse. |
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Authors:
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Curt Wittenberg; Roberto La Valle |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: BioEssays : news and reviews in molecular, cellular and developmental biology Volume: 25 ISSN: 0265-9247 ISO Abbreviation: Bioessays Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-08-25 Completed Date: 2003-09-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8510851 Medline TA: Bioessays Country: United States |
Other Details:
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Languages: eng Pagination: 856-67 Citation Subset: IM |
Copyright Information:
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Copyright 2003 Wiley Periodicals, Inc. |
Affiliation:
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Department of Molecular Biology and Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. curtw@scripps.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle* Cyclin-Dependent Kinases / metabolism Genes, Fungal* Genes, Mating Type, Fungal* Meiosis Models, Biological Pheromones Saccharomyces cerevisiae / genetics*, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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GM43487/GM/NIGMS NIH HHS; GM59441/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Pheromones; EC 2.7.11.22/Cyclin-Dependent Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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