Document Detail


Cell-cycle-regulatory elements and the control of cell differentiation in the budding yeast.
MedLine Citation:
PMID:  12938175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The stable differentiation of cells into other cell types typically involves dramatic reorganization of cellular structures and functions. This often includes remodeling of the cell cycle and the apparatus that controls it. Here we review our understanding of the role and regulation of cell cycle control elements during cell differentiation in the yeast, Saccharomyces cerevisiae. Although the process of differentiation may be more overtly obvious in metazoan organisms, those systems are by nature more difficult to study at a mechanistic level. We consider the relatively well-understood mechanisms by which mating-type switching and the pheromone-induced differentiation of gametes are coupled to the cell cycle as well as the more obscure mechanisms that govern the remodeling of the cell cycle during meiosis and filamentous growth. In some cases, the cell cycle is a primary stimulus for differentiation whereas, in other cases, the signals that promote differentiation alter the cell cycle. Thus, despite relative simplicity of these processes in yeast, the nature of the interplay between the cell cycle and differentiation is diverse.
Authors:
Curt Wittenberg; Roberto La Valle
Related Documents :
10995475 - Combinatorial roles for prb, p107, and p130 in e2f-mediated cell cycle control.
12819135 - Exploration of the cell-cycle genes found within the riken fantom2 data set.
7852115 - Exogenous lactate interferes with cell-cycle control in balb/3t3 mouse fibroblasts.
19002655 - Cell cycle specific expression and nucleolar localization of human j-domain containing ...
15012195 - The great escape: phloem transport and unloading of macromolecules1.
10559525 - Differentiation of coronary smooth muscle cells to a cell cycle-arrested hypertrophic g...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  BioEssays : news and reviews in molecular, cellular and developmental biology     Volume:  25     ISSN:  0265-9247     ISO Abbreviation:  Bioessays     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-25     Completed Date:  2003-09-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8510851     Medline TA:  Bioessays     Country:  United States    
Other Details:
Languages:  eng     Pagination:  856-67     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley Periodicals, Inc.
Affiliation:
Department of Molecular Biology and Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. curtw@scripps.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cell Cycle*
Cyclin-Dependent Kinases / metabolism
Genes, Fungal*
Genes, Mating Type, Fungal*
Meiosis
Models, Biological
Pheromones
Saccharomyces cerevisiae / genetics*,  metabolism*
Grant Support
ID/Acronym/Agency:
GM43487/GM/NIGMS NIH HHS; GM59441/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Pheromones; EC 2.7.11.22/Cyclin-Dependent Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Intrinsically unstructured proteins evolve by repeat expansion.
Next Document:  Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD).