| Cell cycle regulation in the postmitotic neuron: oxymoron or new biology? | |
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MedLine Citation:
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PMID: 17453017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adult CNS neurons are typically described as permanently postmitotic but there is probably nothing permanent about the neuronal cell cycle arrest. Rather, it appears that these highly differentiated cells must constantly keep their cell cycle in check. Relaxation of this vigilance leads to the initiation of a cell cycle and entrance into an altered and vulnerable state, often leading to death. There is evidence that neurons which are at risk of neurodegeneration are also at risk of re-initiating a cell cycle process that involves the expression of cell cycle proteins and DNA replication. Failure of cell cycle regulation might be a root cause of several neurodegenerative disorders and a final common pathway for others. |
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Authors:
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Karl Herrup; Yan Yang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature reviews. Neuroscience Volume: 8 ISSN: 1471-003X ISO Abbreviation: Nat. Rev. Neurosci. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-24 Completed Date: 2007-06-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100962781 Medline TA: Nat Rev Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 368-78 Citation Subset: IM |
Affiliation:
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Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, New Jersey 08854, USA. herrup@biology.rutgers.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / cytology, embryology, growth & development Cell Cycle / physiology* Cell Cycle Proteins / genetics, metabolism* DNA Replication / physiology Humans Models, Biological Neurons / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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