| Cell-cycle regulation in embryonic stem cells: centrosomal decisions on self-renewal. | |
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MedLine Citation:
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PMID: 20594031 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Embryonic stem cells seem to have the intriguing capacity to divide indefinitely while retaining their pluripotency. This self-renewal is accomplished by specialized mechanisms of cell-cycle control. In the last few years, several studies have provided evidence for a direct link between cell-cycle regulation and cell-fate decisions in stem cells. In this review, we discuss the peculiarities of embryonic stem cell-cycle control mechanisms, implicate their involvement in cell-fate decisions, and distinguish centrosomes as important players in the self-renewal versus differentiation roulette. |
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Authors:
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Zuzana Koledova; Alwin Krämer; Leona Raskova Kafkova; Vladimir Divoky |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-09 |
Journal Detail:
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Title: Stem cells and development Volume: 19 ISSN: 1557-8534 ISO Abbreviation: Stem Cells Dev. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101197107 Medline TA: Stem Cells Dev Country: United States |
Other Details:
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Languages: eng Pagination: 1663-78 Citation Subset: IM |
Affiliation:
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Department of Biology, Faculty of Medicine, Palacky University, Olomouc, Czech Republic. zkoledova@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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