| Cell cycle regulation in Trypanosoma brucei. | |
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MedLine Citation:
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PMID: 17335918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell division is regulated by intricate and interconnected signal transduction pathways that precisely coordinate, in time and space, the complex series of events involved in replicating and segregating the component parts of the cell. In Trypanosoma brucei, considerable progress has been made over recent years in identifying molecular regulators of the cell cycle and elucidating their functions, although many regulators undoubtedly remain to be identified, and there is still a long way to go with respect to determining signal transduction pathways. However, it is clear that cell cycle regulation in T. brucei is unusual in many respects. Analyses of trypanosome orthologues of conserved eukaryotic cell cycle regulators have demonstrated divergence of their function in the parasite, and a number of other key regulators are missing from T. brucei. Cell cycle regulation differs in different parasite life cycle stages, and T. brucei appears to use different checkpoint control strategies compared to model eukaryotes. It is therefore probable that T. brucei has evolved novel pathways to control its cell cycle. |
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Authors:
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Tansy C Hammarton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-02-04 |
Journal Detail:
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Title: Molecular and biochemical parasitology Volume: 153 ISSN: 0166-6851 ISO Abbreviation: Mol. Biochem. Parasitol. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-09 Completed Date: 2007-06-21 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8006324 Medline TA: Mol Biochem Parasitol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1-8 Citation Subset: IM |
Affiliation:
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Division of Infection & Immunity and Wellcome Centre for Molecular Parasitology, University of Glasgow, Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, United Kingdom. t.hammarton@bio.gla.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology* Cell Division Cyclin-Dependent Kinases / metabolism Cytokinesis G1 Phase G2 Phase Phosphoric Monoester Hydrolases / metabolism RNA Interference S Phase Signal Transduction Trypanosoma brucei brucei / cytology*, genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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EC 2.7.11.22/Cyclin-Dependent Kinases; EC 3.1.3.-/Phosphoric Monoester Hydrolases |
| Comments/Corrections | |
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