| Cell cycle regulation of the c-Myc transcriptional activation domain. | |
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MedLine Citation:
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PMID: 8321217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The product of the c-myc gene (c-Myc) is a sequence-specific DNA-binding protein that has previously been demonstrated to be required for cell cycle progression. Here we report that the c-Myc DNA binding site confers cell cycle regulation to a reporter gene in Chinese hamster ovary cells. The observed transactivation was biphasic with a small increase in G1 and a marked increase during the S-to-G2/M transition of the cell cycle. This cell cycle regulation of transactivation potential is accounted for, in part, by regulatory phosphorylation of the c-Myc transactivation domain. Together, these data demonstrate that c-Myc may have an important role in the progression of cells through both the G1 and G2 phases of the cell cycle. |
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Authors:
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A Seth; S Gupta; R J Davis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Molecular and cellular biology Volume: 13 ISSN: 0270-7306 ISO Abbreviation: Mol. Cell. Biol. Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-07-30 Completed Date: 1993-07-30 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8109087 Medline TA: Mol Cell Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4125-36 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Binding Sites CHO Cells Cell Cycle / genetics* Cell Line Cricetinae DNA Gene Expression Regulation Genes, myc* Kinetics Molecular Sequence Data Phosphorylation Serine / metabolism Transcription, Genetic* Transcriptional Activation |
| Grant Support | |
ID/Acronym/Agency:
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CA58396/CA/NCI NIH HHS; GM37845/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-45-1/Serine; 9007-49-2/DNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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