| Cell cycle proteins in epithelial cell differentiation: implications for breast cancer. | |
| | |
MedLine Citation:
|
PMID: 20473028 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Proliferation and differentiation are tightly coupled processes, so that a final cell cycle is often linked to the initiation of cell differentiation. The flux in cell cycle proteins during this process is commonly assumed to simply control the final cell cycle exit. However it now appears that cell cycle proteins can also play a role in the decision to continue cycling or to terminally differentiate. A subset of the G1 to S phase transition proteins, D-type cyclins, Rb family proteins and the CDK inhibitors, are particularly involved in the commitment to differentiation. Cell cycle proteins can sequester or modify activators of differentiation pathways, while simultaneously performing their cell cycle functions as illustrated by their roles in terminal differentiation in mammary epithelium. G1 to S phase cell cycle proteins, particularly cyclin D1, are commonly altered in breast cancer and contribute to breast tumorigenesis, presumably by increasing proliferation. However the capacity for cell cycle proteins to also influence differentiation may influence tumour progression, and may alter the efficacy of differentiation-based therapeutics. |
| | |
Authors:
|
C Elizabeth Caldon; Robert L Sutherland; Elizabeth Musgrove |
Related Documents
:
|
10684278 - Genetic studies with the fission yeast schizosaccharomyces pombe suggest involvement of... 19426078 - Can the solar cycle and climate synchronize the snowshoe hare cycle in canada? evidence... 14636838 - An extract of uncaria tomentosa inhibiting cell division and nf-kappa b activity withou... 6542178 - Cinematographic study of the effects of cis-diammine-dichloroplatinum on mouse l cells. 3580908 - The location and orientation of mitotic figures during histogenesis of the rat cerebell... 21305048 - Cell cycle control and dna damage response of conditionally immortalized urothelial cells. |
Publication Detail:
|
Type: Journal Article Date: 2010-05-15 |
Journal Detail:
|
Title: Cell cycle (Georgetown, Tex.) Volume: 9 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2010 May |
Date Detail:
|
Created Date: 2011-01-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
|
Languages: eng Pagination: 1918-28 Citation Subset: IM |
Affiliation:
|
Garvan Institute of Medical Research, Sydney, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The gang of four gene regulates growth and patterning of the developing Drosophila eye.
Next Document: Cancer-associated retinopathy: a new mechanistic insight on vascular remodeling.