Document Detail


Cell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitis.
MedLine Citation:
PMID:  11896158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell cycle proteins regulate processes as diverse as cell division and cell death. Recently their role in neuronal death has been reported in several models of neurodegeneration. We have reported previously that two key regulators of the cell cycle, the retinoblastoma susceptibility gene product (pRb) and transcription factor E2F1, exhibit altered immunostaining patterns in simian immunodeficiency virus encephalitis (SIVE). Here we show that E2F1 and the inactivated, hyperphosphorylated form of pRb (ppRb) also exhibit altered immunostaining patterns in human immunodeficiency virus encephalitis (HIVE). Quantification of E2F1 and ppRb staining by immunofluorescent confocal microscopy confirms a significant increase in E2F1 and ppRb in both HIVE and the simian model. This increase in E2F1 and ppRb staining correlates with an increase in the presence of activated macrophages, suggesting a link between changes in cell cycle proteins and the presence of activated macrophages. Changes in ppRb and E2F1 staining in SIVE also correlate with alterations in E2F/DNA binding complexes present in the nuclear and cytoplasmic fractions from both midfrontal cortex and basal ganglia. These findings suggest that changes in cell cycle proteins occur in both HIVE and the simian model and that these changes have functional implications for gene expression in neural cells under encephalitic conditions mediated by macrophage activation or infiltration.
Authors:
Kelly L Jordan-Sciutto; Guoji Wang; Michael Murphey-Corb; Clayton A Wiley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  22     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-15     Completed Date:  2002-03-27     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2185-95     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
AIDS Dementia Complex / etiology,  metabolism,  pathology
Animals
Astrocytes / metabolism,  pathology
Basal Ganglia / metabolism,  pathology
Biological Markers / analysis
Brain / metabolism*,  pathology
Cell Cycle Proteins / genetics,  metabolism*
Cell Nucleus / metabolism
Cytoplasm / metabolism
DNA / metabolism
DNA-Binding Proteins*
Disease Models, Animal
E2F Transcription Factors
E2F1 Transcription Factor
Frontal Lobe / metabolism,  pathology
Gene Expression Regulation
HIV Infections / complications,  metabolism*,  pathology
Hippocampus / metabolism,  pathology
Humans
Macaca mulatta
Macrophages / metabolism,  virology
Neurons / metabolism,  pathology
Phosphorylation
Protein Binding
Retinoblastoma Protein / metabolism
Simian Acquired Immunodeficiency Syndrome / complications,  metabolism
Species Specificity
Transcription Factors / metabolism
Grant Support
ID/Acronym/Agency:
MH01717/MH/NIMH NIH HHS; MH182273/MH/NIMH NIH HHS; MH46790/MH/NIMH NIH HHS; NS35731/NS/NINDS NIH HHS; NS41202/NS/NINDS NIH HHS; P50 MH45294/MH/NIMH NIH HHS; R01 NS041202/NS/NINDS NIH HHS; R01 NS041202-01/NS/NINDS NIH HHS; R01 NS041202-01S1/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cell Cycle Proteins; 0/DNA-Binding Proteins; 0/E2F Transcription Factors; 0/E2F1 Transcription Factor; 0/E2F1 protein, human; 0/Retinoblastoma Protein; 0/Transcription Factors; 9007-49-2/DNA
Comments/Corrections

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