Document Detail


Cell cycle phase recovery from bleomycin-induced potentially lethal damage.
MedLine Citation:
PMID:  68809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mammalian cells treated during mitosis with the anticancer drug bleomycin cannot recover from potentially lethal damage. G1- and S-phase cells treated in a similar manner can recover. In synchronized G1- and S-phase cells, and in asynchronous and nondividing populations, the final survival values of recovered cells have always been found to be greater than 0.2. These data suggest that a certain fixed amount of recovery can occur, regardless of the degree of initial bleomycin-induced damage. The mechanism of this particular phenomenon is unknown.
Authors:
S C Barranco; W E Bolton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  37     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-09-02     Completed Date:  1977-09-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2589-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bleomycin / pharmacology*
Cell Division*
Cell Survival / drug effects*
Cells, Cultured
Mitosis
Chemical
Reg. No./Substance:
11056-06-7/Bleomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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