Document Detail


Cell-cycle kinetics of cell lines from patients with chromosomal mosaicism.
MedLine Citation:
PMID:  11522248     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lymphocyte cultures from five patients with chromosomal mosaicism (two 47,XY,+21/46,XY, one 47,XX,+21/46,XX, one 45,X/46,XX, and one 47,XXY/46,XY) were studied using sister chromatid differential staining technique for cell kinetic evaluation. Aneuploid and normal cell lines were compared to identify changes in cellular proliferation in vitro that could be related to cellular selective advantage and cell-line-proportion changes occurring with age. Comparison of the percentage of cells in different cell generations in 48, 72, and 96 h-cultures shows no differences between the aneuploid and normal cell lines indicating that cell-cycle kinetics is similar in these cells in vitro.
Authors:
A Bortolai; M I Melaragno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annales de génétique     Volume:  44     ISSN:  0003-3995     ISO Abbreviation:  Ann. Genet.     Publication Date:    2001 Apr-Jun
Date Detail:
Created Date:  2001-08-27     Completed Date:  2001-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370562     Medline TA:  Ann Genet     Country:  France    
Other Details:
Languages:  eng     Pagination:  93-7     Citation Subset:  IM    
Affiliation:
Disciplina de Genética, Universidade Federal de São Paulo (UNIFESP), Rua Botucatu 740, 04023-900, - SP, São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Aneuploidy
Cell Cycle*
Cells, Cultured
Child, Preschool
Chromatids / genetics
Chromosome Disorders / genetics*
Diploidy
Down Syndrome / genetics
Gene Frequency / genetics
Humans
Infant
Karyotyping
Kinetics
Klinefelter Syndrome / genetics
Lymphocytes / metabolism
Metaphase
Mosaicism / genetics*
Probability
Turner Syndrome / genetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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