| Cell cycle inhibition in malignant lymphoma: disease control by attacking the cellular proliferation machinery. | |
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MedLine Citation:
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PMID: 17073597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Disruption of a proper regulation of cell proliferation can ultimately cause cancer. Most human B cell malignancies are driven by chromosomal translocations or other genetic alterations which directly affect the function of critical cell cycle proteins, such as cyclins and cyclin-dependent kinases. In addition, the transformation of indolent lymphomas into aggressive malignancies is often accompanied by a loss of tumor suppressors controlling important cell cycle checkpoints. A better understanding of cell cycle deregulations in human tumors has promoted the introduction of a new class of antiproliferative drugs into cancer therapies. These drugs exert their function by specifically blocking important cell cycle proteins. In the present review we discuss how alterations in the cell cycle control contribute to the malignant transformation of B cells. Furthermore, we provide an overview of novel direct and indirect cell cycle inhibitors and their impact on the treatment of patients with B cell lymphomas. |
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Authors:
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Ingo Ringshausen; Christian Peschel; Thomas Decker |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current drug targets Volume: 7 ISSN: 1873-5592 ISO Abbreviation: Curr Drug Targets Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-10-31 Completed Date: 2007-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960531 Medline TA: Curr Drug Targets Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1349-59 Citation Subset: IM |
Affiliation:
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Comprehensive Cancer Center, University of California, San Francisco, 2340 Sutter Street, San Francisco, CA 94115, USA. iringshausen@cc.ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / pharmacology, therapeutic use* Cell Cycle / drug effects*, physiology Cell Proliferation / drug effects* Growth Inhibitors / pharmacology, therapeutic use* Humans Lymphoma / drug therapy*, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Growth Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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