Document Detail

Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function.
MedLine Citation:
PMID:  19914234     Owner:  NLM     Status:  MEDLINE    
During development, neural progenitor cells or neuroblasts generate a great intra- and inter-segmental diversity of neuronal and glial cell types in the nervous system. In thoracic segments of the embryonic central nervous system of Drosophila, the neuroblast NB6-4t undergoes an asymmetric first division to generate a neuronal and a glial sublineage, while abdominal NB6-4a divides once symmetrically to generate only 2 glial cells. We had earlier reported a critical function for the G1 cyclin, CyclinE (CycE) in regulating asymmetric cell division in NB6-4t. Here we show that (i) this function of CycE is independent of its role in cell cycle regulation and (ii) the two functions are mediated by distinct domains at the protein level. Results presented here also suggest that CycE inhibits the function of Prospero and facilitates its cortical localization, which is critical for inducing stem cell behaviour, i.e. asymmetric cell division of NB6-4t. Furthermore our data imply that CycE is required for the maintenance of stem cell identity of most other neuroblasts.
Christian Berger; Ramakrishnan Kannan; Sudharani Myneni; Simone Renner; L S Shashidhara; Gerhard M Technau
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-13
Journal Detail:
Title:  Developmental biology     Volume:  337     ISSN:  1095-564X     ISO Abbreviation:  Dev. Biol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  415-24     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Inc. All rights reserved.
Institute for Genetics, University of Mainz, D-55099 Mainz, Germany.
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MeSH Terms
Biological Markers / metabolism
Cell Cycle*
Cell Differentiation
Cell Lineage*
Cell Proliferation
Cyclin E / chemistry,  metabolism*
Drosophila Proteins / metabolism*
Drosophila melanogaster / cytology*,  metabolism
Nerve Tissue Proteins / metabolism*
Neurons / cytology*,  metabolism
Nuclear Proteins / metabolism*
Protein Binding
Protein Transport
Sequence Deletion
Transcription Factors / metabolism*
Reg. No./Substance:
0/Biological Markers; 0/Cyclin E; 0/Drosophila Proteins; 0/Nerve Tissue Proteins; 0/Nuclear Proteins; 0/Transcription Factors; 0/pros protein, Drosophila

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