Document Detail

Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells.
MedLine Citation:
PMID:  23154982     Owner:  NLM     Status:  MEDLINE    
Transcription elongation is stimulated by positive transcription elongation factor b (P-TEFb), for which activity is repressed in the 7SK small nuclear ribonucleoprotein (7SK snRNP) complex. We show here a critical role of 7SK snRNP in growth control of primordial germ cells (PGCs). The expression of p15(INK4b), a cyclin-dependent kinase inhibitor (CDKI) gene, in PGCs is selectively activated by P-TEFb and its recruiting molecule, Brd4, when the amount of active P-TEFb is increased due to reduction of the 7SK snRNP, and PGCs consequently undergo growth arrest. These results indicate that CDKI gene-specific control of transcription by 7SK snRNP plays a pivotal role in the maintenance of PGC proliferation.
Daiji Okamura; Ikuma Maeda; Hirofumi Taniguchi; Yuko Tokitake; Makiko Ikeda; Keiko Ozato; Nathan Mise; Kuniya Abe; Toshiaki Noce; Juan Carlos Izpisua Belmonte; Yasuhisa Matsui
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes & development     Volume:  26     ISSN:  1549-5477     ISO Abbreviation:  Genes Dev.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-01-17     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2477-82     Citation Subset:  IM    
Cell Resource Center for Biomedical Research, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Miyagi, Japan.
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MeSH Terms
Cell Cycle
Cell Proliferation
Gene Expression Regulation, Developmental*
Genes, cdc / genetics*
Germ Cells / cytology*,  metabolism*
Mice, Inbred C57BL
Mice, Inbred ICR
Nuclear Proteins / metabolism
Positive Transcriptional Elongation Factor B / metabolism
Ribonucleoproteins / genetics,  metabolism
Ribonucleoproteins, Small Nuclear / genetics,  metabolism
Transcription Factors / metabolism
Reg. No./Substance:
0/Brd4 protein, mouse; 0/Nuclear Proteins; 0/Ribonucleoproteins; 0/Ribonucleoproteins, Small Nuclear; 0/Transcription Factors; EC 2.7.11.-/Positive Transcriptional Elongation Factor B

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