| Cell cycle-dependent regulation of telomere tethering in the nucleus. | |
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MedLine Citation:
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PMID: 18506590 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is well established that telomeres are tethered in the eukaryotic nucleus, but a detailed analysis of the regulation of telomere attachment throughout the cell cycle is still lacking. We show here that the telomeres in the macronucleus of the ciliate Stylonychia lemnae are bound to a sub-nuclear structure by an interaction of the telomere end-binding protein TEBPalpha with three SNS proteins that are integral parts of this structure. In the course of replication, the interaction of TEBPalpha with the SNS proteins is resolved and this process is regulated by cell cycle-specific phosphorylation of the SNS proteins. Our data can be incorporated into a mechanistic model for the regulation of telomere conformation and localization throughout the cell cycle. |
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Authors:
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Katrin Paeschke; Stefan Juranek; Daniela Rhodes; Hans Joachim Lipps |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-29 |
Journal Detail:
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Title: Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology Volume: 16 ISSN: 0967-3849 ISO Abbreviation: Chromosome Res. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-08-08 Completed Date: 2008-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9313452 Medline TA: Chromosome Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 721-8 Citation Subset: IM |
Affiliation:
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Institute of Cell Biology, University Witten/Herdecke, Stockumer Strasse 10, Witten, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle* Cell Nucleus / genetics* Ciliophora / genetics* DNA-Binding Proteins / physiology* Gene Expression Regulation Intranuclear Space Macronucleus / genetics Models, Genetic Nuclear Proteins / genetics Phosphorylation S Phase Telomere / genetics* |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Nuclear Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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