| Cell cycle-dependent regulation of store-operated I(CRAC) and Mg2+-nucleotide-regulated MagNuM (TRPM7) currents. | |
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MedLine Citation:
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PMID: 17064762 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Calcium signaling is a central mechanism for numerous cellular functions and particularly relevant for immune cell proliferation. However, the role of calcium influx in mitotic cell cycle progression is largely unknown. We here report that proliferating rat mast cells RBL-2H3 tightly control their major store-operated calcium influx pathway, I(CRAC), during cell cycle progression. While I(CRAC) is maintained at control levels during the first gap phase (G1), the current is significantly up-regulated in preparation for and during chromatin duplication. However, mitosis strongly suppresses I(CRAC). Non-proliferating cells deprived of growth hormones strongly down-regulate I(CRAC) while increasing cell volume. We further show that the other known calcium (and magnesium) influx pathway in mast cells, the TRPM7-like magnesium-nucleotide-regulated metal (MagNuM) current, is largely uncoupled from cell cycle regulation except in G1. Taken together, our results demonstrate that both store-operated calcium influx via I(CRAC) and MagNuM are regulated at crucial checkpoints during cell cycle progression. |
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Authors:
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Dawn Tani; Mahealani K Monteilh-Zoller; Andrea Fleig; Reinhold Penner |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-10-24 |
Journal Detail:
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Title: Cell calcium Volume: 41 ISSN: 0143-4160 ISO Abbreviation: Cell Calcium Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-07 Completed Date: 2007-06-07 Revised Date: 2012-02-07 |
Medline Journal Info:
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Nlm Unique ID: 8006226 Medline TA: Cell Calcium Country: Scotland |
Other Details:
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Languages: eng Pagination: 249-60 Citation Subset: IM |
Affiliation:
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Laboratory of Cell and Molecular Signaling, Center for Biomedical Research at The Queen's Medical Center and John A. Burns School of Medicine at the University of Hawaii, 1301 Punchbowl Street, UHT 8, Honolulu, HI 96813, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium Channels / metabolism* Calcium Signaling / drug effects, physiology* Cell Line G1 Phase / drug effects, physiology* Intercellular Signaling Peptides and Proteins / metabolism, pharmacology Magnesium / metabolism* Mast Cells / metabolism* Rats TRPM Cation Channels / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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AI050200/AI/NIAID NIH HHS; GM065360/GM/NIGMS NIH HHS; R01-NS040927/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channels; 0/Intercellular Signaling Peptides and Proteins; 0/TRPM Cation Channels; 7439-95-4/Magnesium; EC 2.7.11.1/Trpm7 protein, rat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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