| Cell cycle dependent regulation of the origin recognition complex. | |
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MedLine Citation:
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PMID: 15611627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The eukaryotic origin recognition complex (ORC) not only selects the sites where prereplication complexes are assembled and DNA replication begins, it is the first in a series of multiple coherent pathways that determines when prereplication complexes are assembled. Data from yeast, frogs, flies and mammals present a compelling case that one or more of the six ORC subunits undergoes cell cycle dependent modifications involving phosphorylation and ubiquitination that repress ORC activity during S, G2 and M-phases. ORC activity is not restored until mitosis is complete and a nuclear membrane is present. In yeast, frogs and mammals, the same cyclin-dependent protein kinase [Cdk1(Cdc2)] that initiates mitosis also inhibits assembly of functional ORC/chromatin sites. In yeast, ORC remains bound to chromatin throughout cell division, but in the metazoa either ORC or the Orc1 subunit appears to cycle on and off the chromatin. Thus, this "ORC cycle" is the premier step in preventing rereplication of DNA during a single cell division cycle. |
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Authors:
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Melvin L DePamphilis |
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Publication Detail:
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Type: Journal Article; Review Date: 2005-01-29 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 4 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-03-01 Completed Date: 2006-03-23 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 70-9 Citation Subset: IM |
Affiliation:
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National Institute of Child Health and Human Development, Building 6, Room 3A-15, 9000 Rockville Pike, National Institutes of Health, Bethesda, Maryland 20892-2753, USA. depamphm@mail.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals CDC2 Protein Kinase / genetics, physiology Cell Cycle / genetics, physiology* Cell Division / genetics, physiology Cell Proliferation Chromatin / physiology DNA Replication* / genetics DNA-Binding Proteins / physiology Drosophila melanogaster G2 Phase / genetics, physiology Gene Expression Regulation* Origin Recognition Complex / genetics, physiology* Phosphorylation Protein Binding S Phase / genetics, physiology Saccharomyces cerevisiae Signal Transduction* / genetics Xenopus laevis |
| Chemical | |
Reg. No./Substance:
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0/Chromatin; 0/DNA-Binding Proteins; 0/Origin Recognition Complex; EC 2.7.11.22/CDC2 Protein Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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