Document Detail


Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain.
MedLine Citation:
PMID:  15075296     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pole development is coordinated with the Caulobacter crescentus cell cycle by two-component signaling proteins. We show that an unusual response regulator, PleD, is required for polar differentiation and is sequestered to the cell pole only when it is activated by phosphorylation. Dynamic localization of PleD to the cell pole provides a mechanism to temporally and spatially control the signaling output of PleD during development. Targeting of PleD to the cell pole is coupled to the activation of a C-terminal guanylate cyclase domain, which catalyzes the synthesis of cyclic di-guanosine monophosphate. We propose that the local action of this novel-type guanylate cyclase might constitute a general regulatory principle in bacterial growth and development.
Authors:
Ralf Paul; Stefan Weiser; Nicholas C Amiot; Carmen Chan; Tilman Schirmer; Bernd Giese; Urs Jenal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes & development     Volume:  18     ISSN:  0890-9369     ISO Abbreviation:  Genes Dev.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-12     Completed Date:  2004-05-10     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  715-27     Citation Subset:  IM    
Affiliation:
Division of Molecular Microbiology, Biozentrum, University of Basel, 4056 Basel, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Bacterial Proteins / metabolism*
Caulobacter crescentus / enzymology,  genetics*,  metabolism
Cell Cycle / physiology*
Cyclic GMP / analogs & derivatives*,  biosynthesis
Guanosine Triphosphate / metabolism
Guanylate Cyclase / metabolism*
Phosphorylation
Protein Kinases / metabolism
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/PleD protein, Caulobacter crescentus; 61093-23-0/bis(3',5')-cyclic diguanylic acid; 7665-99-8/Cyclic GMP; 86-01-1/Guanosine Triphosphate; EC 2.7.-/Protein Kinases; EC 2.7.3.-/protein-histidine kinase; EC 4.6.1.2/Guanylate Cyclase
Comments/Corrections

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