| Cell-cycle-dependent changes in membrane potential of L-929 cells caused by the effect of hydrogen peroxide. | |
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MedLine Citation:
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PMID: 10370095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The changes in membrane potential of L-929 fibroblasts caused by H2O2 (10-50 microM) at different phases of the cell cycle were investigated. The membrane potential of cells in G0, early G1, and G2/M responded to H2O2 by hyperpolarizing, while cells in late G1/S responded by depolarizing. Quinidine (50 microM), a blocker of Ca2+-dependent K+ conductance, inhibited the hyperpolarization response of L-929 cells to H2O2 in all cases. Measurements of reactive oxygen species (ROS) production by the cells at the same cell cycle phases indicated that the hyperpolarization response of the cells is linked with minimal production of ROS, and that the depolarization response is associated with maximal production of ROS inside the cell. |
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Authors:
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I A Gamaley; K M Kirpichnikova; I V Artzybasheva; I V Klyubin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 438 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-07-30 Completed Date: 1999-07-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: GERMANY |
Other Details:
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Languages: eng Pagination: 113-5 Citation Subset: IM |
Affiliation:
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Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Ave., 194064 St. Petersburg, Russia. igamaley@link.cytspb.rssi.ru |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / physiology Cell Cycle / physiology* Cell Line Cytophotometry Electrophysiology Fibroblasts Hydrogen Peroxide / pharmacology* Membrane Potentials / drug effects Mice Patch-Clamp Techniques Reactive Oxygen Species |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species; 7440-70-2/Calcium; 7722-84-1/Hydrogen Peroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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