| Cell cycle controls in higher eukaryotic cells: resting state or a prolonged G1 period? | |
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MedLine Citation:
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PMID: 3795989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We express the viewpoint that control over cell growth in higher eukaryotes is achieved predominantly by regular transition of cells from proliferation to rest and vice versa as a result of coordinated interrelationship between intracellular growth inhibitors and extracellular growth factors. The resting state is considered as a special physiological state of a cell where the prereplicative reactions necessary for the onset of DNA synthesis are inhibited. Cells pass into a resting state at each successive cell cycle, with regard to the next cycle, once the threshold level of growth inhibitors has been attained. Cellular rest may thus initiate and proceed in parallel with conventional periods of the cell cycle but in a hidden way. Its termination strictly depends on the appropriate concentration of extracellular growth factors. In the absence of growth factors cells, after completing mitosis, pass into an overt state of rest metabolically different from any period of the cell cycle including G1. |
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Authors:
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O I Epifanova; V A Polunovsky |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of theoretical biology Volume: 120 ISSN: 0022-5193 ISO Abbreviation: J. Theor. Biol. Publication Date: 1986 Jun |
Date Detail:
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Created Date: 1987-01-23 Completed Date: 1987-01-23 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376342 Medline TA: J Theor Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 467-77 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle* Cell Division Cricetinae Cricetulus DNA Replication Eukaryotic Cells / physiology Hela Cells / physiology Humans Interphase* Models, Biological |
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