Document Detail


Cell cycle control of pituitary development and disease.
MedLine Citation:
PMID:  18987159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pituitary gland regulates diverse physiological functions, including growth, metabolism, reproduction, stress response, and ageing. Early genetic models in the mouse taught us that the pituitary is highly sensitive to genetic alteration of specific cell cycle regulators such as the retinoblastoma protein (pRB) or the cell cycle inhibitor p27(Kip1). The molecular analysis of human pituitary neoplasias has now corroborated that cell cycle deregulation is significantly implicated in pituitary tumorigenesis. In particular, proteins involved in cyclin-dependent kinase regulation or the pRB pathway are altered in nearly all human pituitary tumors. Additional cell cycle regulators such as PTTG1/securin may have critical roles in promoting genomic instability in pituitary neoplasias. Recent experimental data suggest that these cell cycle regulators may have significant implications in the biology of putative progenitor cells and pituitary homeostasis. Understanding how cell cycle regulation controls pituitary biology may provide us with new therapeutic approaches against pituitary diseases.
Authors:
Victor Quereda; Marcos Malumbres
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-11-05
Journal Detail:
Title:  Journal of molecular endocrinology     Volume:  42     ISSN:  1479-6813     ISO Abbreviation:  J. Mol. Endocrinol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-29     Completed Date:  2009-04-13     Revised Date:  2013-10-01    
Medline Journal Info:
Nlm Unique ID:  8902617     Medline TA:  J Mol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  75-86     Citation Subset:  IM    
Affiliation:
Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, E-28029 Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle*
Cyclin-Dependent Kinases / metabolism
Humans
Pituitary Diseases / enzymology,  pathology*
Pituitary Gland / cytology*,  embryology*,  enzymology
Pituitary Neoplasms / enzymology,  pathology
Grant Support
ID/Acronym/Agency:
08-0188//Association for International Cancer Research
Chemical
Reg. No./Substance:
EC 2.7.11.22/Cyclin-Dependent Kinases

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