Document Detail

Cell cycle control and cancer chemotherapy.
MedLine Citation:
PMID:  8014193     Owner:  NLM     Status:  MEDLINE    
As detailed information accumulates about how cell cycle events are regulated, we can expect new opportunities for application to cancer therapy. The altered expression of oncogenes and tumor suppressor genes that commonly occurs in human cancers may impair the ability of the cells to respond to metabolic perturbations of stress. Impaired cell cycle regulation would make cells vulnerable to pharmacologic intervention by drug regimens tailored to the defects existing in particular tumors. Recent findings that may become applicable to therapy are reviewed, and the possible form of new therapeutic stratagems is considered.
K W Kohn; J Jackman; P M O'Connor
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cellular biochemistry     Volume:  54     ISSN:  0730-2312     ISO Abbreviation:  J. Cell. Biochem.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-07-26     Completed Date:  1994-07-26     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8205768     Medline TA:  J Cell Biochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  440-52     Citation Subset:  IM    
Laboratory of Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
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MeSH Terms
Cell Cycle / genetics*
DNA Damage
DNA Replication
G1 Phase / physiology
Gene Expression Regulation, Neoplastic*
Mitosis / physiology
Neoplasms / drug therapy*,  genetics
S Phase / physiology
Tumor Suppressor Protein p53 / physiology
Reg. No./Substance:
0/Tumor Suppressor Protein p53

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