| Cell cycle control by oscillating regulatory proteins in Caulobacter crescentus. | |
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MedLine Citation:
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PMID: 16547950 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Significant strides have been made in recent years towards understanding the molecular basis of cell cycle progression in the model bacterium Caulobacter crescentus. At the heart of cell cycle regulation is a multicomponent transcriptional feedback loop, governing the production of successive regulatory waves or pulses of at least three master regulatory proteins. These oscillating master regulators direct the execution of phase-specific events and, importantly, through intrinsic genetic switches not only determine the length of a given phase, but also provide the driving force that catapults the cell into the next stage of the cell cycle. The genetic switches act as fail safe mechanisms that prevent the cell cycle from relapsing and thus govern the ordered production and the periodicity of these regulatory waves. Here, we detail how the master regulators CtrA, GcrA and DnaA coordinate cell cycle progression and polar development in Caulobacter. |
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Authors:
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Julia Holtzendorff; Jens Reinhardt; Patrick H Viollier |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: BioEssays : news and reviews in molecular, cellular and developmental biology Volume: 28 ISSN: 0265-9247 ISO Abbreviation: Bioessays Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-28 Completed Date: 2006-05-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8510851 Medline TA: Bioessays Country: United States |
Other Details:
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Languages: eng Pagination: 355-61 Citation Subset: IM |
Affiliation:
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UMR 7144-CNRS-UPMC, Station Biologique de Roscoff, Plankton, France 29680, Roscoff, France. holtzendorff@sb-roscoff.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Proteins
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genetics,
metabolism* Caulobacter crescentus / cytology*, genetics, metabolism* Cell Cycle* Chromosomes, Bacterial / genetics DNA-Binding Proteins / genetics, metabolism* Transcription Factors / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/DNA-Binding Proteins; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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