| Cell cycle control by an essential bacterial two-component signal transduction protein. | |
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MedLine Citation:
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PMID: 8548829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dividing cells must coordinate cell cycle events to ensure genetic stability. Here we identify an essential two-component signal transduction protein that controls multiple events in the Caulobacter cell cycle, including cell division, stalk synthesis, and cell cycle-specific transcription. This protein, CtrA, is homologous to response regulator transcription factors and controls transcription from a group of cell cycle-regulated promoters critical for DNA replication, DNA methylation, and flagellar biogenesis. CtrA activity in the cell cycle is controlled both transcriptionally and by phosphorylation. As purified CtrA binds an essential DNA sequence motif found within its target promoters, we propose that CtrA acts in a phosphorelay signal transduction system to control bacterial cell cycle events directly at the transcriptional level. |
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Authors:
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K C Quon; G T Marczynski; L Shapiro |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cell Volume: 84 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 1996 Jan |
Date Detail:
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Created Date: 1996-02-22 Completed Date: 1996-02-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 83-93 Citation Subset: IM |
Affiliation:
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Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, California 94305-5427, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/U39559 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Bacterial Proteins / genetics Base Sequence Caulobacter / cytology*, physiology Cell Cycle / physiology Cell Cycle Proteins / genetics Conserved Sequence Escherichia coli / physiology Gene Expression Regulation, Bacterial / physiology Molecular Sequence Data Phenotype Phosphorylation Promoter Regions, Genetic / genetics Signal Transduction / physiology* Transcription, Genetic / physiology |
| Grant Support | |
ID/Acronym/Agency:
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GM 32506/512OMZ/GM/NIGMS NIH HHS; GM5 1426/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Cell Cycle Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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