Document Detail


Cell cycle control by an essential bacterial two-component signal transduction protein.
MedLine Citation:
PMID:  8548829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dividing cells must coordinate cell cycle events to ensure genetic stability. Here we identify an essential two-component signal transduction protein that controls multiple events in the Caulobacter cell cycle, including cell division, stalk synthesis, and cell cycle-specific transcription. This protein, CtrA, is homologous to response regulator transcription factors and controls transcription from a group of cell cycle-regulated promoters critical for DNA replication, DNA methylation, and flagellar biogenesis. CtrA activity in the cell cycle is controlled both transcriptionally and by phosphorylation. As purified CtrA binds an essential DNA sequence motif found within its target promoters, we propose that CtrA acts in a phosphorelay signal transduction system to control bacterial cell cycle events directly at the transcriptional level.
Authors:
K C Quon; G T Marczynski; L Shapiro
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell     Volume:  84     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-02-22     Completed Date:  1996-02-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  83-93     Citation Subset:  IM    
Affiliation:
Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, California 94305-5427, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/U39559
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Bacterial Proteins / genetics
Base Sequence
Caulobacter / cytology*,  physiology
Cell Cycle / physiology
Cell Cycle Proteins / genetics
Conserved Sequence
Escherichia coli / physiology
Gene Expression Regulation, Bacterial / physiology
Molecular Sequence Data
Phenotype
Phosphorylation
Promoter Regions, Genetic / genetics
Signal Transduction / physiology*
Transcription, Genetic / physiology
Grant Support
ID/Acronym/Agency:
GM 32506/512OMZ/GM/NIGMS NIH HHS; GM5 1426/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Cell Cycle Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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