| Cell cycle control of Notch signaling and the functional regionalization of the neuroepithelium during vertebrate neurogenesis. | |
| | |
MedLine Citation:
|
PMID: 19598111 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A critical feature of vertebrate neural precursors is the to-and-fro displacement of their nuclei as cell cycle progresses, thus giving rise to a pseudostratified epithelium. This nuclear behavior, referred to as interkinetic nuclear migration (INM), is translated into the disposition of the cell somas at different orthogonal levels depending on the cell cycle stage they are. The finding that important regulators of neurogenesis, such as the proneural and neurogenic genes, undergo cyclic changes of expression and function in coordination with the cell cycle and the INM, and that the neurogenic process correlates with a particular window of the cell cycle, in coincidence with the apical localization in the neuroepithelium of neural precursors, is a novel concept that facilitates our understanding of the neurogenic process in vertebrates. As such, recent data support the notion that the three-dimensional structure of the neuroepithelium is crucial for proper neuronal production. In this review, we describe current knowledge of the molecular mechanisms involved in the differential expression and function of the proneural and neurogenic gene products along the cell cycle, and we discuss important consequences for vertebrate neurogenesis derived from this observation. |
| | |
Authors:
|
Maria Jesús Latasa; Elsa Cisneros; Jose María Frade |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: The International journal of developmental biology Volume: 53 ISSN: 1696-3547 ISO Abbreviation: Int. J. Dev. Biol. Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-07-14 Completed Date: 2009-10-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8917470 Medline TA: Int J Dev Biol Country: Spain |
Other Details:
|
Languages: eng Pagination: 895-908 Citation Subset: IM |
Affiliation:
|
Instituto de Investigaciones Biomedicas Alberto Sols, CSIC, Madrid, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Cycle / physiology Cell Differentiation Cell Nucleus / physiology Models, Neurological Movement Neuroepithelial Cells / cytology*, physiology* Neurogenesis / genetics, physiology* Receptors, Notch / genetics, physiology* Signal Transduction Vertebrates |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Notch |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Primordial germ cell biology at the beginning of the XXI century.
Next Document: Revisiting old vaginal topics: conversion of the Müllerian vagina and origin of the "sinus" vagina.